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Debasis Dash

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Debasis Dash
Born (1972-06-17) 17 June 1972 (age 52)
Bhubaneswar, India
NationalityIndian
Known forStudies on computational biology
Awards
Scientific career
Fields
Institutions

Debasis Dash is an Indian computational biologist and chief scientist at the Institute of Genomics and Integrative Biology (IGIB).[1][2] Known for his research on proteomics[3][4][5] and Big Data and Artificial Intelligence studies,[6][7] his studies have been documented by way of a number of articles[8] and ResearchGate,[9] an online repository of scientific articles has listed 120 of them.[10] The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2014.[11] He was appointed as the director of Institute of Life Sciences, Bhubaneswar on 18 May 2023.[3][12]

Biography

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Debasis Dash, born on 17 June 1972 in Bhubaneswar, completed his master's degree in chemistry at Delhi University before securing a PhD in 1998. He joined IGIB as scientist in 2000 where he now serves as professor and head for Big Data and AI decision Unit. His contributions have led to the establishment of a thriving school in the realm of genome, proteome and health care informatics.

One of Dr. Dash's notable achievements includes the development of award-winning commercial software suites such as PLHost[13] and Genocluster,[14] which garnered recognition at the Bangalore Bio conferences in 2005[15] and 2006[16] for the best product presentation. Collaborating with researchers utilizing the PLHost tool, Dr. Dash's team identified novel genes coding for chromatin remodeling proteins called INO-80, as published in the esteemed Online Mendelian Inheritance in Man (OMIM) database.[17] He has been also part of renowned Open Source Drug Discovery project[18] and Indian Genome Variation Consortium, the largest study conducted on healthy individuals in India to catalog basal genomic variation across diverse populations. In the realm of virology, Dr. Dash's unique GeneD'cipher algorithm identified three novel genes in the SARS virus,[19] aiding in its diagnosis during the outbreak in China. His exceptional contribution in this area received extensive media coverage, with headlines such as "Indian scientists develop Gene Decipher to fight against SARS" featured in prominent publications like India Today, Economic Times, and The Hindu. Additionally, Dr. Dash played a crucial role in establishing the GN Ramachandran Knowledge Centre for Genome Informatics at IGIB.

Combining genomics and proteomics, Dr. Dash ventured into proteogenomics, developing computational algorithms and associated software suites like MassWiz,[3] flexifdr,[20] and ProteoStats.[21] Through his systematic analysis of proteomics data, he made significant discoveries, including the identification of proteins in human plasma, M. tuberculosis,[22] agriculturally important symbiont B. Japonicum,[23] and the missing proteome in humans.[24] In last 5 years, Dr. Dash has also made notable contributions to the development of AI-based medical imaging tools. He has worked on projects such as CovBaseAI project, focusing on the detection and diagnosis of COVID-19 pneumonia from chest X-rays.[7] He has also been involved in the RAPID-CT, aiming to reduce turnaround time and prioritize patients based on their condition using automated triage of medical images. Furthermore, Dr. Dash has worked on the identification and classification of Interstitial Lung Diseases (ILD) from CT scans, aiming to develop a system for texture-based analysis and quantification.

Dr. Debasis Dash's multidisciplinary expertise and pioneering research have significantly advanced the fields of genome informatics and AI in healthcare. His contributions have not only led to scientific breakthroughs but also fostered the growth of bioinformatics research in India. Furthermore, his efforts have resulted in the establishment of a vibrant school of genome informatics in India, with many of his trained students receiving prestigious fellowships and holding faculty positions at renowned institutions like IIT, IISER, THSTI, and Delhi University.

In summary, Dr. Debasis Dash's remarkable scientific journey in genome informatics has left an indelible mark on the field of biological sciences. His innovative ideas, pioneering algorithms, and impactful research have garnered international recognition, positioning CSIR-IGIB as a leading institution in bioinformatics. Through his contributions to genomics, proteomics, and proteogenomics, Dr. Dash has significantly advanced our understanding of biological systems, revolutionizing the way we approach diagnostics, drug discovery, and personalized medicine.

Awards and honors

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Patents

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  • A computer based method for identifying peptides useful as drug targets.
         US, PCT: NF64/2000; Samir K. Brahmachari and Debasis Dash
  • A computer based method for predicting protein coding DNA sequences useful as drug targets.
         US, PCT: NF 421/03; S.K. Brahmachari, D. Dash, J.K Maheshwari and R. Sharma

International Collaborations

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Selected bibliography

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  • Dhar, Mahesh S.; Marwal, Robin; Vs, Radhakrishnan; Ponnusamy, Kalaiarasan; Jolly, Bani; Bhoyar, Rahul C.; Sardana, Viren; Naushin, Salwa; Rophina, Mercy; Mellan, Thomas A.; Mishra, Swapnil; Whittaker, Charles; Fatihi, Saman; Datta, Meena; Singh, Priyanka (19 November 2021). "Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India". Science. 374 (6570): 995–999. doi:10.1126/science.abj9932. ISSN 0036-8075. PMC 7612010. PMID 34648303.
  • Singh, Prateek; Ujjainiya, Rajat; Prakash, Satyartha; Naushin, Salwa; Sardana, Viren; Bhatheja, Nitin; Singh, Ajay Pratap; Barman, Joydeb; Kumar, Kartik; Gayali, Saurabh; Khan, Raju; Rawat, Birendra Singh; Tallapaka, Karthik Bharadwaj; Anumalla, Mahesh; Lahiri, Amit (1 July 2022). "A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys". Computers in Biology and Medicine. 146: 105419. doi:10.1016/j.compbiomed.2022.105419. ISSN 0010-4825.
  • Ujjainiya, Rajat; Tyagi, Akansha; Sardana, Viren; Naushin, Salwa; Bhatheja, Nitin; Kumar, Kartik; Barman, Joydeb; Prakash, Satyartha; Kutum, Rintu; Bhaskar, Akash Kumar; Singh, Prateek; Chaudhary, Kumardeep; Loomba, Menka; Khanna, Yukti; Walecha, Chestha (1 April 2022). "High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge". Nature Communications. 13 (1): 1726. doi:10.1038/s41467-022-29404-3. ISSN 2041-1723.
  • Kumar, Dhirendra; Yadav, Amit Kumar; Jia, Xinying; Mulvenna, Jason; Dash, Debasis (1 January 2016). "Integrated Transcriptomic-Proteomic Analysis Using a Proteogenomic Workflow Refines Rat Genome Annotation*". Molecular & Cellular Proteomics. 15 (1): 329–339. doi:10.1074/mcp.M114.047126. ISSN 1535-9476.
  • Yadav, Amit Kumar; Bhardwaj, Gourav; Basak, Trayambak; Kumar, Dhirendra; Ahmad, Shadab; Priyadarshini, Ruby; Singh, Ashish Kumar; Dash, Debasis; Sengupta, Shantanu (7 September 2011). "A Systematic Analysis of Eluted Fraction of Plasma Post Immunoaffinity Depletion: Implications in Biomarker Discovery". PLOS ONE. 6 (9): e24442. doi:10.1371/journal.pone.0024442. ISSN 1932-6203. PMC 3168506. PMID 21931718.
  • Singh, Gajinder Pal; Ganapathi, Mythily; Dash, Debasis (11 December 2006). "Role of intrinsic disorder in transient interactions of hub proteins". Proteins: Structure, Function, and Bioinformatics. 66 (4): 761–765. doi:10.1002/prot.21281.

References

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  1. ^ "DD Lab". sites.google.com. Retrieved 2 June 2023.
  2. ^ "Debasis Dash". Institute of Genomics and Integrative Biology. Retrieved 2 June 2023.
  3. ^ a b c "Debasis Dash appointed Director- Institute of Life Sciences, Bhubaneswar". 18 May 2023. Retrieved 30 May 2023.
  4. ^ Kumar, Dhirendra; Yadav, Amit Kumar; Jia, Xinying; Mulvenna, Jason; Dash, Debasis (1 January 2016). "Integrated Transcriptomic-Proteomic Analysis Using a Proteogenomic Workflow Refines Rat Genome Annotation*". Molecular & Cellular Proteomics. 15 (1): 329–339. doi:10.1074/mcp.M114.047126. ISSN 1535-9476. PMC 4762527. PMID 26560066.
  5. ^ Kumar, Dhirendra; Bansal, Gourja; Narang, Ankita; Basak, Trayambak; Abbas, Tahseen; Dash, Debasis (October 2016). "Integrating transcriptome and proteome profiling: Strategies and applications". Proteomics. 16 (19): 2533–2544. doi:10.1002/pmic.201600140. PMID 27343053. S2CID 13333376.
  6. ^ Singh, Prateek; Ujjainiya, Rajat; Prakash, Satyartha; Naushin, Salwa; Sardana, Viren; Bhatheja, Nitin; Singh, Ajay Pratap; Barman, Joydeb; Kumar, Kartik; Gayali, Saurabh; Khan, Raju; Rawat, Birendra Singh; Tallapaka, Karthik Bharadwaj; Anumalla, Mahesh; Lahiri, Amit (1 July 2022). "A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys". Computers in Biology and Medicine. 146: 105419. doi:10.1016/j.compbiomed.2022.105419. ISSN 0010-4825. PMC 9040372. PMID 35483225.
  7. ^ a b Gidde, Prashant Sadashiv; Prasad, Shyam Sunder; Singh, Ajay Pratap; Bhatheja, Nitin; Prakash, Satyartha; Singh, Prateek; Saboo, Aakash; Takhar, Rohit; Gupta, Salil; Saurav, Sumeet; M. V., Raghunandanan; Singh, Amritpal; Sardana, Viren; Mahajan, Harsh; Kalyanpur, Arjun (1 December 2021). "Validation of expert system enhanced deep learning algorithm for automated screening for COVID-Pneumonia on chest X-rays". Scientific Reports. 11 (1): 23210. Bibcode:2021NatSR..1123210G. doi:10.1038/s41598-021-02003-w. ISSN 2045-2322. PMC 8636645. PMID 34853342. S2CID 224817359.
  8. ^ "On Google Scholar". Google Scholar. 12 May 2018. Retrieved 12 May 2018.
  9. ^ "Debasis Dash". ResearchGate. Retrieved 2 June 2023.
  10. ^ "On ResearchGate". 12 May 2018. Retrieved 12 May 2018.
  11. ^ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 November 2017.
  12. ^ Pioneer, The. "Debasis Dash appointed as ILS Director". The Pioneer. Retrieved 2 June 2023.
  13. ^ "Jalaja Tech's bioinformatics software completes test trials". test.pharmabiz.com. Retrieved 2 June 2023.
  14. ^ "Genocluster with four softwares: PLHost, SeaPath, Proteome Kalculator and GeneDCfer". CSIR. Retrieved 2 June 2023.
  15. ^ "Bangalore Bio 2005". www.biospectrumindia.com. Retrieved 2 June 2023.
  16. ^ "Bangalore Bio 2006 gains momentum". www.biospectrumindia.com. Retrieved 2 June 2023.
  17. ^ Bakshi, Rachit; Prakash, Tulika; Dash, Debasis; Brahmachari, Vani (16 July 2004). "In silico characterization of the INO80 subfamily of SWI2/SNF2 chromatin remodeling proteins". Biochemical and Biophysical Research Communications. 320 (1): 197–204. doi:10.1016/j.bbrc.2004.05.147. ISSN 0006-291X. PMID 15207721.
  18. ^ "Open Source Drug Discovery". www.osdd.net. Archived from the original on 20 October 2015. Retrieved 2 June 2023.
  19. ^ "Recognition and analysis of protein-coding genes in severe acute respiratory syndrome associated coronavirus". academic.oup.com. Retrieved 2 June 2023.
  20. ^ Yadav, Amit Kumar; Kumar, Dhirendra; Dash, Debasis (26 November 2012). "Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results". PLOS ONE. 7 (11): e50651. Bibcode:2012PLoSO...750651Y. doi:10.1371/journal.pone.0050651. ISSN 1932-6203. PMC 3506577. PMID 23189209.
  21. ^ academic.oup.com https://academic.oup.com/bioinformatics/article-abstract/29/21/2799/197053. Retrieved 2 June 2023. {{cite web}}: Missing or empty |title= (help)
  22. ^ Kelkar, Dhanashree S.; Kumar, Dhirendra; Kumar, Praveen; Balakrishnan, Lavanya; Muthusamy, Babylakshmi; Yadav, Amit Kumar; Shrivastava, Priyanka; Marimuthu, Arivusudar; Anand, Sridhar; Sundaram, Hema; Kingsbury, Reena; Harsha, H. C.; Nair, Bipin; Prasad, T. S. Keshava; Chauhan, Devendra Singh (1 December 2011). "Proteogenomic Analysis of Mycobacterium tuberculosis By High Resolution Mass Spectrometry*". Molecular & Cellular Proteomics. 10 (12): M111.011445. doi:10.1074/mcp.M111.011627. ISSN 1535-9476. PMC 3275902. PMID 21969609. S2CID 36626951.
  23. ^ Kumar, Dhirendra; Yadav, Amit Kumar; Kadimi, Puneet Kumar; Nagaraj, Shivashankar H.; Grimmond, Sean M.; Dash, Debasis (1 November 2013). "Proteogenomic Analysis of Bradyrhizobium japonicum USDA110 Using Genosuite, an Automated Multi-algorithmic Pipeline*". Molecular & Cellular Proteomics. 12 (11): 3388–3397. doi:10.1074/mcp.M112.027169. ISSN 1535-9476. PMC 3820949. PMID 23882027.
  24. ^ Kumar, Dhirendra; Jain, Aradhya; Dash, Debasis (4 December 2015). "Probing the Missing Human Proteome: A Computational Perspective". Journal of Proteome Research. 14 (12): 4949–4958. doi:10.1021/acs.jproteome.5b00728. ISSN 1535-3893. PMID 26407240.
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